HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: H3C (Q6NXT2)
Histone H3.3C (Histone H3.5)
Gene: H3-5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 135
+	Hs
		934804 EZH2_HUMAN (1-746): 0: 862: 100.00		H31_HUMAN (1-135): 4.22e-57: 175: 92.65
+	Hs
		952363 EZH2_HUMAN (1-746): 0: 862: 100.00		H33_HUMAN (1-135): 1.39e-56: 174: 94.85
+	Hs
		1079993 EZH2_HUMAN (1-746): 0: 862: 100.00		H31T_HUMAN (1-135): 2.09e-56: 173: 89.71
+	Mm
		952747 EZH2_MOUSE (1-746): 0: 860: 98.39		H33_MOUSE (1-135): 1.39e-56: 174: 94.85
+	Mm
		952754 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		H33_MOUSE (1-135): 1.39e-56: 174: 94.85
+	Dm
		356072 EZ_DROME (8-745): 0: 712: 52.70		H3_DROME (1-135): 5.98e-56: 172: 93.38
+	Dm
		356118 ASH1_DROME (196-732): 2.08e-99: 339: 18.55		H3_DROME (1-135): 5.98e-56: 172: 93.38
+	Hs
		331780 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H31_HUMAN (1-135): 4.22e-57: 175: 92.65
+	Hs
		331787 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H33_HUMAN (1-135): 1.39e-56: 174: 94.85
+	Hs
		331823 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H31T_HUMAN (1-135): 2.09e-56: 173: 89.71
+	Hs
		331833 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H32_HUMAN (1-135): 5.98e-56: 172: 93.38
+	Hs
		935129 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H31_HUMAN (1-135): 4.22e-57: 175: 92.65
+	Hs
		935204 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		H31_HUMAN (1-135): 4.22e-57: 175: 92.65
+	Hs
		952555 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H33_HUMAN (1-135): 1.39e-56: 174: 94.85
+	Hs
		1086280 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H31T_HUMAN (1-135): 2.09e-56: 173: 89.71
+	Hs
		1086306 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		H31T_HUMAN (1-135): 2.09e-56: 173: 89.71
+	Sc
		755791 SET1_YEAST (205-733): 1.13e-84: 292: 16.01		H3_YEAST (1-135): 4.1e-51: 160: 85.29
+	Hs
		331748 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		CENPA_HUMAN (9-132): 2.48e-39: 130: 47.69
+	Hs
		828350 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		CENPA_HUMAN (9-132): 2.48e-39: 130: 47.69
+	Sp
		223811 CLR4_SCHPO (330-726): 8.94e-80: 265: 19.09		H31_SCHPO (1-135): 2.06e-54: 168: 86.77