HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: H2AV (Q71UI9)
Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)
Gene: H2AZ2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 128
+	Hs
		1080241 EZH2_HUMAN (1-746): 0: 862: 100.00		H2A1H_HUMAN (5-125): 4.19e-54: 167: 62.30
+	Hs
		391719 EZH2_HUMAN (1-746): 0: 862: 100.00		H2A1B_HUMAN (5-125): 1.25e-53: 166: 62.30
+	Hs
		470396 EZH2_HUMAN (1-746): 0: 862: 100.00		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		470127 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H2AZ_HUMAN (1-127): 3.62e-60: 182: 98.43
+	Hs
		331824 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A2C_HUMAN (5-128): 2.15e-54: 168: 62.40
+	Hs
		331703 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		331860 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A1C_HUMAN (5-125): 9.3e-54: 166: 62.30
+	Hs
		470164 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		H2AZ_HUMAN (1-127): 3.62e-60: 182: 98.43
+	Hs
		470126 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		H2AZ_HUMAN (1-127): 3.62e-60: 182: 98.43
+	Hs
		470560 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		470506 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		555602 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		H2AX_HUMAN (5-124): 1.36e-53: 166: 62.81
+	Hs
		203696 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		H2A2C_HUMAN (5-128): 2.15e-54: 168: 62.40
+	Hs
		203730 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		H2A2B_HUMAN (5-127): 1.29e-54: 168: 60.48
+	Sc
		810384 SET2_YEAST (470-733): 1.22e-59: 216: 25.56		H2AZ_YEAST (4-126): 3.22e-39: 129: 66.67
+	Hs
		391662 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		H2A1B_HUMAN (5-125): 1.25e-53: 166: 62.30
+	Hs
		470359 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30
+	Hs
		165613 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		H2A1B_HUMAN (5-125): 1.25e-53: 166: 62.30
+	Hs
		165615 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		H2A1_HUMAN (5-125): 1.18e-53: 166: 62.30