HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: PELP1 (Q8IZL8)
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
Gene: PELP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27634302
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 1130
+	Hs
		1080420 EZH2_HUMAN (1-746): 0: 862: 100.00		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Hs
		554310 EZH2_HUMAN (1-746): 0: 862: 100.00		MUC1_HUMAN (443-1092): 6.43e-28: 124: 11.79
+	Hs
		998760 EZH2_HUMAN (1-746): 0: 862: 100.00		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		1080127 EZH2_HUMAN (1-746): 0: 862: 100.00		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28
+	Hs
		1080261 EZH2_HUMAN (1-746): 0: 862: 100.00		MINT_HUMAN (731-1119): 1.09e-10: 68.5: 12.18
+	Hs
		1080413 EZH2_HUMAN (1-746): 0: 862: 100.00		OGFR_HUMAN (675-871): 2.97e-09: 63.3: 21.00
+	Hs
		1080112 EZH2_HUMAN (1-746): 0: 862: 100.00		CRBG2_HUMAN (567-1130): 6.66e-09: 62.4: 11.34
+	Hs
		331812 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		MDC1_HUMAN (411-1014): 5.18e-12: 72.8: 11.24
+	Hs
		1056940 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		MDC1_HUMAN (411-1014): 5.18e-12: 72.8: 11.24
+	Hs
		1056971 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		MDC1_HUMAN (411-1014): 5.18e-12: 72.8: 11.24
+	Mm
		1225199 EHMT2_MOUSE (467-732): 2.28e-68: 247: 24.56		CHAP1_MOUSE (750-1123): 3.35e-09: 63.1: 12.37
+	Hs
		975298 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		165705 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		165667 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		975285 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28
+	Hs
		1243853 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28
+	Hs
		165699 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28