HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28068325, 27634302
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 1214
+	Hs
		1080198 EZH2_HUMAN (1-746): 0: 862: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		1272933 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		975289 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		975301 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		232183 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		1080413 EZH2_HUMAN (1-746): 0: 862: 100.00		OGFR_HUMAN (804-1190): 3.3e-13: 76.2: 16.02
+	Hs
		1080127 EZH2_HUMAN (1-746): 0: 862: 100.00		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Sc
		755777 SET1_YEAST (205-733): 1.13e-84: 292: 16.01		RSC8_YEAST (336-751): 4.61e-104: 342: 28.30
+	Hs
		231945 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Dm
		800671 SUV39_DROME (382-736): 1.78e-70: 244: 19.62		LSDA_DROME (273-542): 3.86e-56: 213: 17.27
+	Hs
		160147 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Mm
		1169805 EHMT2_MOUSE (467-732): 2.28e-68: 247: 24.56		KDM1A_MOUSE (254-543): 9.03e-44: 174: 15.05
+	Hs
		232430 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		203599 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		1296427 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		RERE_HUMAN (759-1212): 1.19e-09: 65: 16.17
+	Hs
		975338 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		RERE_HUMAN (759-1212): 1.19e-09: 65: 16.17
+	Hs
		1350538 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		RERE_HUMAN (759-1212): 1.19e-09: 65: 16.17
+	Hs
		975285 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		1243853 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		165699 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57