HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0021766 - hippocampus development
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 1164
+	Hs
		1051290 EZH2_HUMAN (1-746): 0: 862: 100.00		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		724847 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		148867 EZH2_HUMAN (1-746): 0: 862: 100.00		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		551721 EZH2_HUMAN (1-746): 0: 862: 100.00		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Mm
		1142297 EZH2_MOUSE (1-746): 0: 860: 98.39		MY18A_MOUSE (693-1156): 2.57e-14: 80.2: 9.53
+	Hs
		1080073 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11
+	Hs
		725169 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		254514 SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10		ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27
+	Hs
		148166 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		149336 ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148704 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		165745 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67