HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	27634302, 32064169, 31866294, 32453339, 33849069, 31130994, 35163710, 20800574
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042752 - regulation of circadian rhythm GO:0048511 - rhythmic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 1102
+	Hs
		1273798 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1273884 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		203754 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1080483 EZH2_HUMAN (1-746): 0: 862: 100.00		UBP22_HUMAN (45-521): 2.51e-107: 347: 16.43
+	Hs
		1080357 EZH2_HUMAN (1-746): 0: 862: 100.00		UBP42_HUMAN (162-683): 1.67e-95: 334: 18.44
+	Hs
		1080417 EZH2_HUMAN (1-746): 0: 862: 100.00		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13
+	Hs
		203721 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		UBP34_HUMAN (125-644): 3.97e-99: 348: 18.81
+	Hs
		203753 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		USP9X_HUMAN (173-554): 7.42e-97: 341: 23.08
+	Hs
		203811 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		UBP24_HUMAN (200-587): 2.93e-95: 337: 24.41