HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: H2A1H (Q96KK5)
Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)
Gene: H2AC12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 128
+	Hs
		391719 EZH2_HUMAN (1-746): 0: 862: 100.00		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		470396 EZH2_HUMAN (1-746): 0: 862: 100.00		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Dm
		785621 EZ_DROME (8-745): 0: 712: 52.70		H2A_DROME (17-125): 5.6e-59: 179: 89.91
+	Hs
		331703 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		331860 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A1C_HUMAN (1-128): 6.95e-67: 199: 98.44
+	Hs
		331824 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H2A2C_HUMAN (1-124): 8.56e-65: 194: 98.39
+	Hs
		470560 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		470506 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		555602 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		H2AX_HUMAN (1-124): 2.04e-63: 191: 94.36
+	Hs
		203730 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		H2A2B_HUMAN (1-128): 1.07e-65: 196: 95.31
+	Hs
		203696 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		H2A2C_HUMAN (1-124): 8.56e-65: 194: 98.39
+	Sc
		392487 SET2_YEAST (470-733): 1.22e-59: 216: 25.56		H2A2_YEAST (16-127): 1.11e-58: 179: 81.25
+	Hs
		391662 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		470359 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00
+	Hs
		165613 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		H2A1B_HUMAN (1-128): 1.07e-66: 199: 98.44
+	Hs
		165615 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		H2A1_HUMAN (1-128): 6.72e-67: 199: 100.00