HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: CEP63 (Q96MT8)
Centrosomal protein of 63 kDa (Cep63)
Gene: CEP63

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.573

Property	Details
Experiments	25416956, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 703
+	Hs
		725169 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH10_HUMAN (145-703): 1.35e-24: 112: 10.78
+	Hs
		724847 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		148867 EZH2_HUMAN (1-746): 0: 862: 100.00		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Mm
		1142297 EZH2_MOUSE (1-746): 0: 860: 98.39		MY18A_MOUSE (51-573): 5.66e-15: 81.2: 13.17
+	Hs
		331895 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		DAPLE_HUMAN (37-586): 4.1e-41: 164: 17.08
+	Hs
		148166 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		149336 ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		148704 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29