HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: RSF1 (Q96T23)
Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)
Gene: RSF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27634302
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006355 - regulation of DNA-templated transcription GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 1441
+	Hs
		1080172 EZH2_HUMAN (1-746): 0: 862: 100.00		ELYS_HUMAN (74-1393): 4.64e-49: 194: 9.68
+	Hs
		725169 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH10_HUMAN (277-1341): 9.72e-46: 183: 10.59
+	Hs
		1068540 EZH2_HUMAN (1-746): 0: 862: 100.00		PLEC_HUMAN (101-1361): 2.59e-41: 169: 11.90
+	Hs
		724847 EZH2_HUMAN (1-746): 0: 862: 100.00		MYH9_HUMAN (265-1324): 2.49e-38: 159: 10.69
+	Hs
		1080262 EZH2_HUMAN (1-746): 0: 862: 100.00		UHRF1_HUMAN (654-1274): 9.34e-39: 158: 13.05
+	Hs
		1018505 EZH2_HUMAN (1-746): 0: 862: 100.00		CHD3_HUMAN (475-1062): 1.62e-36: 153: 14.78
+	Hs
		1080446 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5B_HUMAN (747-972): 3.49e-35: 149: 23.45
+	Mm
		1149802 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		PLEC_MOUSE (101-1362): 1.36e-40: 167: 11.00
+	Hs
		666533 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5A_HUMAN (798-972): 1.38e-26: 120: 23.12
+	Hs
		1080299 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5D_HUMAN (754-972): 7.07e-24: 112: 17.78
+	Hs
		1080127 EZH2_HUMAN (1-746): 0: 862: 100.00		KMT2C_HUMAN (830-1420): 8.08e-19: 95.9: 11.64
+	Hs
		1059639 EZH2_HUMAN (1-746): 0: 862: 100.00		CHD4_HUMAN (877-960): 3.83e-14: 80.1: 28.57
+	Mm
		102330 EZH2_MOUSE (1-746): 0: 860: 98.39		G3UWZ0_MOUSE (894-941): 5.56e-12: 72.9: 52.08
+	Hs
		152654 EZH2_HUMAN (1-746): 0: 862: 100.00		KMT2D_HUMAN (881-1008): 1.91e-10: 68.1: 21.88
+	Mm
		1125396 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		Q5DTP7_MOUSE (877-960): 4.87e-14: 79.7: 28.57
+	Ce
		184558 MES2_CAEEL (108-736): 1.84e-138: 428: 25.93		CHD3_CAEEL (648-1158): 2.6e-34: 146: 12.86
+	Ce
		104623 MES2_CAEEL (108-736): 1.84e-138: 428: 25.93		LE418_CAEEL (609-962): 1.4e-13: 78.5: 13.73
+	Hs
		331816 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		PLEC_HUMAN (101-1361): 2.59e-41: 169: 11.90
+	Hs
		331899 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		BAZ2A_HUMAN (404-1029): 4.52e-32: 139: 11.65
+	Hs
		331813 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		CHD4_HUMAN (877-960): 3.83e-14: 80.1: 28.57