HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: TRI55 (Q9BYV6)
Tripartite motif-containing protein 55 (EC 2.3.2.27) (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)
Gene: TRIM55

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	31391242
Identification Methods	two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 548
+	Hs
		1080208 EZH2_HUMAN (1-746): 0: 862: 100.00		TRI63_HUMAN (8-329): 1.6e-80: 257: 61.30
+	Hs
		584972 EZH2_HUMAN (1-746): 0: 862: 100.00		RO52_HUMAN (12-405): 3.8e-74: 245: 15.87
+	Hs
		1029465 EZH2_HUMAN (1-746): 0: 862: 100.00		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		1080481 EZH2_HUMAN (1-746): 0: 862: 100.00		TRI33_HUMAN (25-531): 1.06e-65: 233: 10.86
+	Hs
		1080310 EZH2_HUMAN (1-746): 0: 862: 100.00		TRIM4_HUMAN (18-370): 8.1e-64: 218: 15.17
+	Hs
		585025 EZH1_HUMAN (15-745): 0: 745: 63.48		RO52_HUMAN (12-405): 3.8e-74: 245: 15.87
+	Hs
		1080055 EZH2_HUMAN (1-746): 0: 862: 100.00		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Hs
		1317504 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		TRI55_HUMAN (1-548): 6.44e-121: 368: 100.00
+	Hs
		331804 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		1317576 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		TRI31_HUMAN (12-426): 1.42e-62: 213: 17.35
+	Hs
		1282033 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		TRI63_HUMAN (8-329): 1.6e-80: 257: 61.30
+	Hs
		1029886 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		1029752 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		203676 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		331832 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Hs
		165624 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		RO52_HUMAN (12-405): 3.8e-74: 245: 15.87
+	Hs
		1171583 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Hs
		165672 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		TIF1B_HUMAN (18-534): 7.29e-67: 233: 15.37
+	Hs
		1171280 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Hs
		975275 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39