HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: SKI8 (Q9GZS3)
Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]
Gene: SKIC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	27634302, 16169070
Identification Methods	affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 305
+	Hs
		1080207 EZH2_HUMAN (1-746): 0: 862: 100.00		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		209441 EZH2_HUMAN (1-746): 0: 862: 100.00		PLRG1_HUMAN (4-217): 2.47e-43: 156: 22.52
+	Hs
		267764 EZH2_HUMAN (1-746): 0: 862: 100.00		TAF5L_HUMAN (24-208): 1.33e-09: 60.8: 25.76
+	Hs
		1317584 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		NLE1_HUMAN (7-304): 9.15e-91: 279: 21.61
+	Hs
		331862 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		1288291 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		1281314 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Zm
		35725 A0A1D6M742_MAIZE (377-733): 7.66e-86: 287: 16.59		A0A1D6LQJ4_MAIZE (2-216): 1.11e-49: 169: 20.18
+	Hs
		1288292 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		975320 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		SKI8_HUMAN (1-305): 2.86e-101: 300: 100.00
+	Hs
		903444 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		203735 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		DAW1_HUMAN (182-303): 5.93e-35: 132: 26.02
+	At
		1319861 ATX1_ARATH (449-728): 1.09e-59: 220: 22.57		WDR5A_ARATH (184-303): 3.4e-37: 136: 32.80
+	Hs
		975303 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		975304 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		903149 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		903609 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		165657 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Dm
		1129076 SET1_DROME (611-732): 1.27e-18: 93.2: 38.71		WDS_DROME (2-95): 1.13e-16: 81.2: 21.88