HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 626
+	Hs
		1080173 EZH2_HUMAN (1-746): 0: 862: 100.00		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		1080207 EZH2_HUMAN (1-746): 0: 862: 100.00		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Mm
		1141957 EZH2_MOUSE (1-746): 0: 860: 98.39		RBBP7_MOUSE (311-580): 1.59e-37: 146: 15.31
+	Mm
		1141960 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		RBBP7_MOUSE (311-580): 1.59e-37: 146: 15.31
+	Hs
		997735 EZH2_HUMAN (1-746): 0: 862: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Mm
		1141929 EZH2_MOUSE (1-746): 0: 860: 98.39		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Mm
		1141935 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Mm
		936647 EZH1_MOUSE (15-745): 0: 755: 63.61		RBBP7_MOUSE (311-580): 1.59e-37: 146: 15.31
+	Mm
		936646 EZH1_MOUSE (15-745): 0: 755: 63.61		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		997839 EZH1_HUMAN (15-745): 0: 745: 63.48		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		1317584 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		NLE1_HUMAN (181-575): 1.3e-63: 219: 12.70
+	Hs
		1281314 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		331862 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Zm
		35725 A0A1D6M742_MAIZE (377-733): 7.66e-86: 287: 16.59		A0A1D6LQJ4_MAIZE (395-623): 2.06e-43: 160: 8.73
+	Hs
		1288291 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		903444 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		1288292 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Mm
		1141954 EHMT2_MOUSE (467-732): 2.28e-68: 247: 24.56		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55
+	Ce
		219656 LIN59_CAEEL (329-736): 3.77e-67: 243: 16.85		LIN53_CAEEL (251-477): 2.75e-20: 95.7: 15.73
+	Mm
		222465 SUV91_MOUSE (354-731): 1.7e-71: 240: 18.88		RBBP4_MOUSE (233-477): 2.84e-19: 92.6: 14.55