Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 25332235, 25515538, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EZH2_WD-Binding~WD40, SET~WD40
Common GO terms GO:0005634 - nucleus
GO:0045892 - negative regulation of DNA-templated transcription
GO:0048511 - rhythmic process
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 746
Hs

1 542
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024