HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 456
+	Mm
		888071 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		1080488 EZH2_HUMAN (1-746): 0: 862: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Mm
		1149804 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		RUVB2_MOUSE (2-455): 0: 651: 42.76
+	Hs
		1296444 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1296442 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		203815 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		810383 SET2_YEAST (470-733): 1.22e-59: 216: 25.56		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Hs
		165742 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		RUVB2_HUMAN (2-455): 0: 651: 42.76