HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: PRC2C (Q9Y520)
Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)
Gene: PRRC2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	27634302
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 2896
+	Hs
		1080263 EZH2_HUMAN (1-746): 0: 862: 100.00		MUC4_HUMAN (41-2889): 6.61e-93: 341: 8.51
+	Hs
		1080261 EZH2_HUMAN (1-746): 0: 862: 100.00		MINT_HUMAN (22-1891): 2.31e-43: 178: 9.12
+	Hs
		554310 EZH2_HUMAN (1-746): 0: 862: 100.00		MUC1_HUMAN (1225-2237): 6.18e-39: 162: 13.66
+	Hs
		1080127 EZH2_HUMAN (1-746): 0: 862: 100.00		KMT2C_HUMAN (1901-2885): 8.54e-14: 80.6: 9.27
+	Hs
		1080126 EZH2_HUMAN (1-746): 0: 862: 100.00		RTL9_HUMAN (1727-2594): 7.38e-11: 70.4: 12.16
+	Hs
		1271101 EZH1_HUMAN (15-745): 0: 745: 63.48		DIDO1_HUMAN (88-631): 5.4e-37: 156: 16.09
+	Hs
		820995 EZH1_HUMAN (15-745): 0: 745: 63.48		PRC2A_HUMAN (1183-2870): 8.38e-21: 103: 8.16
+	Hs
		1300928 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		CIC_HUMAN (57-1435): 3.5e-10: 68.5: 9.73
+	Hs
		1127674 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		PRC2B_HUMAN (894-2896): 3.68e-13: 78.3: 6.73
+	Hs
		1300945 EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27		CIC_HUMAN (57-1435): 3.5e-10: 68.5: 9.73
+	Hs
		1296398 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		CIC_HUMAN (57-1435): 3.5e-10: 68.5: 9.73
+	Dm
		1215699 TRR_DROME (611-732): 1.53e-18: 93.2: 40.65		SPEN_DROME (140-2892): 2.28e-30: 135: 7.86
+	Dm
		1129083 SET1_DROME (611-732): 1.27e-18: 93.2: 38.71		Q9VLS7_DROME (1208-2548): 1.93e-23: 111: 9.16
+	Hs
		975294 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		TITIN_HUMAN (1221-2896): 4.19e-20: 101: 7.44
+	Hs
		975285 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		KMT2C_HUMAN (1901-2885): 8.54e-14: 80.6: 9.27
+	Hs
		1243853 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		KMT2C_HUMAN (1901-2885): 8.54e-14: 80.6: 9.27
+	Hs
		165699 SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71		KMT2C_HUMAN (1901-2885): 8.54e-14: 80.6: 9.27
+	Hs
		975251 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		NCOA6_HUMAN (37-1027): 9.61e-13: 76.7: 7.69
+	Hs
		1057804 SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52		NCOA6_HUMAN (37-1027): 9.61e-13: 76.7: 7.69