HitPredict

Interactor 1: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	12672821, 10801818, 28514442, 34079125, 33961781, 35271311
Identification Methods	two hybrid, unspecified method, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LIM~WH1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Hs			1 591
+	Hs
		1237868 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		ENAH_HUMAN (1-591): 2.13e-77: 258: 100.00
+	Hs
		359 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		A0A075B6E5_HUMAN (1-162): 2.4e-58: 196: 74.69
+	Hs
		1078829 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Dm
		1210945 Q8I0G8_DROME (276-572): 3.5e-75: 249: 37.37		ENA_DROME (2-491): 1.84e-26: 116: 23.88
+	Dm
		1137155 Q5U0W6_DROME (276-569): 8.42e-74: 246: 37.08		ENA_DROME (2-491): 1.84e-26: 116: 23.88
+	Hs
		160013 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		HGS_HUMAN (90-385): 6.31e-28: 120: 22.22
+	Hs
		1080810 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		1237898 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		ENAH_HUMAN (1-591): 2.13e-77: 258: 100.00
+	Hs
		1260462 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		840482 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Rn
		1101450 TES_RAT (294-571): 6.62e-27: 115: 15.36		Q5XHX3_RAT (1-591): 2.43e-63: 219: 58.38
+	Hs
		840600 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		840535 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		975400 ZYX_MOUSE (1-572): 3.2e-62: 216: 85.02		ENAH_MOUSE (242-591): 1.85e-17: 88.4: 74.57
+	Hs
		1191615 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		SPRE1_HUMAN (2-314): 1.71e-57: 201: 18.58
+	Ce
		136803 Q3S1I9_CAEEL (401-572): 5.41e-47: 168: 28.00		UNC89_CAEEL (112-571): 5.62e-26: 116: 9.91
+	Hs
		823356 PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		1355072 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		1336727 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		MYO10_HUMAN (182-480): 4.53e-25: 112: 14.15
+	Hs
		840599 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18