HitPredict

Interactor 1: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Interactor 2: PDLI5 (Q96HC4)
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)
Gene: PDLIM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	25416956, 34079125
Identification Methods	two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005912 - adherens junction GO:0015629 - actin cytoskeleton GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Hs			1 596
+	Hs
		1080808 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		TES_HUMAN (278-593): 3.29e-62: 213: 18.29
+	Hs
		1080745 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LPP_HUMAN (106-590): 2.49e-49: 182: 16.13
+	Hs
		1080753 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		AJUBA_HUMAN (79-593): 6.42e-48: 177: 15.28
+	Hs
		1294459 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		AJUBA_HUMAN (79-593): 6.42e-48: 177: 15.28
+	Hs
		823405 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		PAXI_HUMAN (98-534): 3.23e-32: 133: 13.50
+	Hs
		238967 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LPXN_HUMAN (188-535): 9.33e-30: 123: 15.21
+	Hs
		1080796 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		PDLI7_HUMAN (475-594): 1.12e-28: 121: 28.33
+	Hs
		823508 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		PAXI_HUMAN (98-534): 3.23e-32: 133: 13.50
+	Hs
		823403 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		PAXI_HUMAN (98-534): 3.23e-32: 133: 13.50
+	Hs
		238998 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		LPXN_HUMAN (188-535): 9.33e-30: 123: 15.21
+	Hs
		1344047 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		PDLI7_HUMAN (475-594): 1.12e-28: 121: 28.33
+	Hs
		238966 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		LPXN_HUMAN (188-535): 9.33e-30: 123: 15.21
+	Hs
		1076405 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		TRIP6_HUMAN (99-542): 4.54e-22: 101: 14.71
+	Hs
		1076563 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		TRIP6_HUMAN (99-542): 4.54e-22: 101: 14.71
+	Hs
		1076487 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		TRIP6_HUMAN (99-542): 4.54e-22: 101: 14.71
+	Hs
		1044598 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		FHL3_HUMAN (393-472): 1.36e-09: 61.4: 22.47
+	Hs
		1080809 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LIMD1_HUMAN (538-596): 7.25e-09: 60.8: 28.81
+	Mm
		936362 TRIP6_MOUSE (63-571): 3.86e-70: 235: 34.30		PDLI4_MOUSE (536-593): 7.92e-11: 65.7: 25.86
+	Hs
		1355150 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		LIMD1_HUMAN (538-596): 7.25e-09: 60.8: 28.81
+	Hs
		816247 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		LIMS1_HUMAN (436-573): 4.46e-10: 63.2: 29.37