HitPredict

Interactor 1: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Interactor 2: PDLI7 (Q9NR12)
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
Gene: PDLIM7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	34079125, 28514442
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005912 - adherens junction GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 572 Hs			1 457
+	Hs
		1344047 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		1080745 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LPP_HUMAN (85-457): 5.09e-56: 197: 19.02
+	Hs
		1080809 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LIMD1_HUMAN (78-457): 6.82e-53: 190: 17.84
+	Hs
		1080753 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		AJUBA_HUMAN (115-457): 1.26e-52: 187: 17.04
+	Hs
		1355150 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		LIMD1_HUMAN (78-457): 6.82e-53: 190: 17.84
+	Hs
		1294459 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		AJUBA_HUMAN (115-457): 1.26e-52: 187: 17.04
+	Hs
		823405 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		PAXI_HUMAN (185-396): 1.45e-33: 135: 21.23
+	Hs
		238967 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		LPXN_HUMAN (73-397): 1.08e-31: 126: 16.00
+	Hs
		823508 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		PAXI_HUMAN (185-396): 1.45e-33: 135: 21.23
+	Hs
		1080752 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		PDLI5_HUMAN (1-282): 6.17e-28: 118: 24.82
+	Hs
		823403 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		PAXI_HUMAN (185-396): 1.45e-33: 135: 21.23
+	Hs
		238998 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		LPXN_HUMAN (73-397): 1.08e-31: 126: 16.00
+	Hs
		238966 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		LPXN_HUMAN (73-397): 1.08e-31: 126: 16.00
+	Hs
		1044598 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		FHL3_HUMAN (304-449): 9.17e-16: 79.3: 28.38
+	Mm
		936362 TRIP6_MOUSE (63-571): 3.86e-70: 235: 34.30		PDLI4_MOUSE (398-457): 1.19e-12: 70.7: 26.67
+	Hs
		1076405 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		816247 TRIP6_HUMAN (63-571): 6e-66: 224: 32.82		LIMS1_HUMAN (298-452): 6.05e-14: 74.3: 24.54
+	Hs
		1076563 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		1076487 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42