HitPredict

Interactor 1: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Interactor 2: EVL (Q9UI08)
Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)
Gene: EVL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	28514442, 32296183, 34079125, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LIM~WH1
Common GO terms	GO:0001725 - stress fiber GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Hs			1 416
+	Hs
		1260462 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		EVL_HUMAN (1-416): 1.85e-85: 268: 100.00
+	Hs
		359 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		A0A075B6E5_HUMAN (1-151): 7.6e-73: 229: 57.96
+	Hs
		840482 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		840600 LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		840535 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Dm
		1210945 Q8I0G8_DROME (276-572): 3.5e-75: 249: 37.37		ENA_DROME (2-386): 1.01e-40: 156: 24.68
+	Dm
		1137155 Q5U0W6_DROME (276-569): 8.42e-74: 246: 37.08		ENA_DROME (2-386): 1.01e-40: 156: 24.68
+	Hs
		1355072 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		EVL_HUMAN (1-416): 1.85e-85: 268: 100.00
+	Hs
		1080725 ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		1237868 FBLI1_HUMAN (252-572): 4.13e-67: 224: 29.61		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		823356 PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		840599 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Mm
		975400 ZYX_MOUSE (1-572): 3.2e-62: 216: 85.02		ENAH_MOUSE (98-415): 5.28e-11: 66.6: 32.72
+	Hs
		1191615 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		SPRE1_HUMAN (2-165): 1.31e-48: 173: 26.74
+	Hs
		840541 LPP_HUMAN (4-495): 1.9e-13: 75.1: 13.92		VASP_HUMAN (1-412): 5.97e-57: 193: 41.59
+	Hs
		1190444 LIMS2_HUMAN (384-544): 8.75e-10: 62.4: 27.55		SPRE1_HUMAN (2-165): 1.31e-48: 173: 26.74
+	Rn
		1101450 TES_RAT (294-571): 6.62e-27: 115: 15.36		Q5XHX3_RAT (184-415): 4.84e-29: 120: 40.66
+	Hs
		1237898 TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		1237872 AJUBA_HUMAN (9-499): 2.93e-13: 74.3: 11.33		ENAH_HUMAN (94-415): 1.88e-29: 122: 32.24
+	Hs
		279845 LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95		TRIO_HUMAN (135-408): 7.1e-30: 124: 13.48