HitPredict

Interactor 1: HSPB2 (Q16082)
Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) (Heat shock protein family B member 2)
Gene: HSPB2

Interactor 2: HSPB8 (Q9UJY1)
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
Gene: HSPB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	14594798, 11342557
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 182 Hs			1 196
+	Hs
		388788 HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85		HSPB8_HUMAN (1-196): 7.92e-71: 214: 100.00
+	Hs
		358699 CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		388468 HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		388144 HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Rn
		621311 CRYAB_RAT (6-174): 2.8e-56: 176: 34.50		HSPB1_RAT (1-179): 4.16e-61: 190: 36.41
+	Hs
		358697 CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358941 CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		359021 HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358696 CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Hs
		1378434 V9HW27_HUMAN (6-174): 2.32e-55: 174: 35.67		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358950 HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Bt
		358695 CRYAB_BOVIN (6-174): 1.35e-55: 175: 35.09		CRYAA_BOVIN (6-190): 1.34e-51: 165: 24.32
+	Hs
		147844 HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85		HSPB6_HUMAN (5-166): 4.57e-44: 146: 31.10
+	Hs
		1080859 HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		358767 CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		1022259 HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00		HSPB3_HUMAN (55-171): 7.7e-30: 109: 25.42