HitPredict

Interactor 1: CCDC6 (Q16204)
Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)
Gene: CCDC6

Interactor 2: RPTOR (Q8N122)
Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Gene: RPTOR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 38580884
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 1335
+	Hs
		724912 MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78		RPTOR_HUMAN (1-1335): 0: 1440: 100.00
+	Hs
		1081118 CCDC6_HUMAN (1-474): 2.18e-48: 174: 100.00		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		1263249 RUFY2_HUMAN (59-346): 8.08e-24: 106: 19.87		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		1051392 DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		1281519 MRCKB_HUMAN (23-351): 2.44e-20: 96.6: 14.57		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		724952 MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		1268063 MY18A_HUMAN (62-328): 1.49e-10: 65.8: 15.87		FBXW7_HUMAN (961-1324): 5.17e-69: 248: 15.18
+	Hs
		792983 DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02		LIS1_HUMAN (1101-1334): 4.69e-55: 199: 15.69
+	Bt
		60990 A5PKJ3_BOVIN (2-361): 9.82e-21: 97.8: 13.76		LIS1_BOVIN (1101-1334): 5.73e-55: 199: 15.69
+	Hs
		903399 MY18A_HUMAN (62-328): 1.49e-10: 65.8: 15.87		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Hs
		148610 CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Hs
		903240 PLEC_HUMAN (67-346): 2.74e-09: 61.9: 11.79		WDR5_HUMAN (1099-1334): 2.05e-64: 224: 16.88
+	Dm
		1001737 Q9VVC8_DROME (23-339): 6.69e-31: 127: 61.18		Q0KHS0_DROME (1067-1320): 3.43e-17: 89.5: 21.32
+	Hs
		61736 A6H8W8_HUMAN (55-316): 4.69e-24: 108: 19.93		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58
+	Hs
		502910 MYH3_HUMAN (48-349): 1.75e-09: 62.3: 11.88		TLE3_HUMAN (1165-1335): 2.38e-23: 109: 13.07
+	Hs
		863446 ITSN1_HUMAN (14-474): 1.6e-22: 103: 11.38		COPA_HUMAN (1009-1182): 1.34e-10: 68.3: 17.62
+	Hs
		728492 MYH11_HUMAN (54-323): 1.64e-09: 62.6: 17.07		POC1A_HUMAN (932-1114): 1.11e-17: 89.1: 9.96
+	Hs
		149156 CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78		SNR40_HUMAN (1246-1335): 6.58e-16: 82.9: 17.58
+	Hs
		148462 CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78		COPB2_HUMAN (1197-1333): 5.9e-15: 82.2: 15.83
+	Hs
		148570 CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78		COPA_HUMAN (1009-1182): 1.34e-10: 68.3: 17.62