HitPredict

Interactor 1: HIF1 (G5EGD2)
Hypoxia-inducible factor 1 (Hypoxia-induced factor 1)
Gene: hif-1

Interactor 2: Q9BKZ8 (Q9BKZ8)
Nuclear receptor domain-containing protein
Gene: nhr-239

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 719 Ce			1 262
+	Ce
		108098 HIF1_CAEEL (1-719): 0: 731: 100.00		NH111_CAEEL (11-86): 2.87e-21: 92.4: 51.32
+	Ce
		108094 HIF1_CAEEL (1-719): 0: 731: 100.00		NHR62_CAEEL (2-89): 1.49e-18: 86.7: 46.67
+	Hs
		126103 BMAL1_HUMAN (4-530): 3.58e-129: 398: 15.16		RXRA_HUMAN (10-245): 1.13e-67: 218: 22.95
+	Hs
		369025 ARNT_HUMAN (2-560): 2.82e-131: 408: 18.03		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Hs
		369703 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Hs
		320210 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		ERR2_HUMAN (7-218): 4.32e-58: 192: 21.10
+	Hs
		510022 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		ERR1_HUMAN (4-222): 6.86e-57: 189: 21.78
+	Hs
		914652 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		ERR3_HUMAN (2-218): 1.79e-55: 186: 19.73
+	Hs
		370292 EPAS1_HUMAN (2-466): 7.27e-124: 391: 22.67		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Mm
		864795 ARNT_MOUSE (2-622): 1.01e-125: 394: 16.81		ERR2_MOUSE (7-218): 2.94e-57: 190: 20.18
+	Mm
		864788 ARNT_MOUSE (2-622): 1.01e-125: 394: 16.81		ERR3_MOUSE (2-218): 1.79e-55: 186: 19.73
+	Mm
		956581 EPAS1_MOUSE (2-604): 1.09e-119: 381: 18.69		ERR2_MOUSE (7-218): 2.94e-57: 190: 20.18
+	Hs
		649056 ARNT_HUMAN (2-560): 2.82e-131: 408: 18.03		HNF4A_HUMAN (2-148): 4.68e-45: 159: 34.69
+	Mm
		914681 EPAS1_MOUSE (2-604): 1.09e-119: 381: 18.69		ERR3_MOUSE (2-218): 1.79e-55: 186: 19.73
+	Hs
		782560 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		HNF4A_HUMAN (2-148): 4.68e-45: 159: 34.69
+	Hs
		126108 BMAL1_HUMAN (4-530): 3.58e-129: 398: 15.16		HNF4A_HUMAN (2-148): 4.68e-45: 159: 34.69
+	Hs
		369684 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		ESR1_HUMAN (2-217): 2.05e-59: 199: 22.12
+	Hs
		500364 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		RARB_HUMAN (9-258): 6.57e-57: 189: 20.46
+	Hs
		490063 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		NR2F6_HUMAN (3-113): 4.52e-46: 160: 41.44
+	Dm
		404411 SIM_DROME (13-493): 6.75e-107: 342: 18.53		HR78_DROME (11-88): 2.56e-18: 85.9: 50.00