HitPredict

Interactor 1: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.51 1.00 0.715

The method score is based on:

Property Details
Experiments 35384245
Identification Methods affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, I-set~LRR_8, ig~I-set, LRR_8~ig, LRRCT_2~ig, LRR_8~LRR_8, LRRCT_2~LRR_8, LRR_8~LRRNT, LRR_8~PK_Tyr_Ser-Thr, LRRNT~LRRNT, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0008284 - positive regulation of cell population proliferation
GO:0010628 - positive regulation of gene expression
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Last updated: 15 Jul 2024