HitPredict

Interactor 1: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Interactor 2: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 839 Hs			1 508
+	Hs
		647902 NTRK2_HUMAN (6-839): 0: 557: 52.87		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		384307 NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		385052 NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		384487 NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75		KC1E_HUMAN (21-455): 3.27e-110: 335: 23.06
+	Hs
		507867 FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		384472 NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75		KC1A_HUMAN (17-366): 5.32e-106: 321: 24.72
+	Hs
		507838 FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		507947 FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43		KC1G2_HUMAN (24-392): 2.53e-96: 299: 22.25
+	Hs
		434232 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		434225 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		411424 INSR_HUMAN (513-824): 1.34e-64: 238: 39.43		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		647876 ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		968416 ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		411417 INSR_HUMAN (513-824): 1.34e-64: 238: 39.43		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		537755 INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		568630 ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		943109 DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63		KC1G2_HUMAN (24-392): 2.53e-96: 299: 22.25
+	Hs
		169186 MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00