HitPredict

Interactor 1: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Interactor 2: FRS2 (Q8WU20)
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Gene: FRS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	10092678, 35384245
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 508
+	Hs
		1083873 NTRK2_HUMAN (6-839): 0: 557: 52.87		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		385225 NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		609443 FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		601554 FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		508122 FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Mm
		555269 FGFR1_MOUSE (162-838): 6.06e-163: 496: 23.71		FRS2_MOUSE (1-508): 0: 577: 95.87
+	Hs
		608060 FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		207292 FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43		FRS3_HUMAN (1-508): 8.04e-165: 477: 47.51
+	Mm
		555270 FGFR1_MOUSE (162-838): 6.06e-163: 496: 23.71		FRS3_MOUSE (1-508): 3.38e-156: 455: 47.41
+	Hs
		434249 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		1081513 NTRK3_HUMAN (1-839): 0: 671: 100.00		DOK6_HUMAN (20-186): 2.83e-53: 184: 25.00
+	Mm
		1101896 NTRK3_MOUSE (1-839): 0: 661: 95.59		DOK6_MOUSE (20-186): 3.41e-53: 184: 25.00
+	Hs
		411450 INSR_HUMAN (513-824): 1.34e-64: 238: 39.43		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		434273 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		235038 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Hs
		434219 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		DOK6_HUMAN (20-186): 2.83e-53: 184: 25.00
+	Hs
		434248 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		DOK4_HUMAN (20-191): 2.87e-49: 174: 15.03
+	Hs
		434299 RET_HUMAN (282-837): 1.5e-108: 360: 25.76		DOK5_HUMAN (20-177): 8.93e-42: 153: 17.61
+	Hs
		411486 INSR_HUMAN (513-824): 1.34e-64: 238: 39.43		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Mm
		546269 INSR_MOUSE (513-824): 2.11e-62: 231: 38.80		DOK1_MOUSE (14-332): 4.77e-85: 272: 18.82