HitPredict

Interactor 1: EXT1 (Q16394)
Exostosin-1 (EC 2.4.1.225) (Exostosin glycosyltransferase 1) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 1) (N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase)
Gene: EXT1

Interactor 2: EXT2 (Q93063)
Exostosin-2 (EC 2.4.1.224) (Exostosin glycosyltransferase 2) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 2)
Gene: EXT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 10679296, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Glyco_transf_64~Glyco_transf_64
Common GO terms GO:0000139 - Golgi membrane
GO:0000271 - polysaccharide biosynthetic process
GO:0001503 - ossification
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus
and 19 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 746
Hs

1 718
+ Hs
+ Hs
+ Dm
+ Hs
+ Dm
+ Hs
+ Dm
+ Ce
+ At
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024