HitPredict

Interactor 1: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Interactor 2: DEFI8 (Q6ZN54)
Differentially expressed in FDCP 8 homolog (DEF-8)
Gene: DEF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~Pkinase
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 984 Hs			1 512
+	Hs
		408621 PKN1_HUMAN (15-984): 0: 940: 56.24		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		1160243 PKN3_HUMAN (12-215): 6.12e-17: 88.2: 20.69		DEFI8_HUMAN (1-512): 0: 698: 100.00
+	Hs
		397122 KPCG_HUMAN (497-980): 2.52e-147: 456: 33.52		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		397135 KPCG_HUMAN (497-980): 2.52e-147: 456: 33.52		KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83
+	Hs
		397120 KPCG_HUMAN (497-980): 2.52e-147: 456: 33.52		KPCG_HUMAN (151-250): 1.42e-18: 90.9: 15.84
+	Hs
		984482 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		KPCD_HUMAN (153-250): 5.85e-21: 98.6: 17.93
+	Hs
		408608 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		566367 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83
+	Hs
		969084 KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00		KPCE_HUMAN (151-250): 8.06e-23: 104: 17.43
+	Hs
		981048 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		KPCT_HUMAN (201-250): 1.39e-14: 78.6: 24.00
+	Hs
		566395 KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00		KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83
+	Hs
		984512 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		GRP3_HUMAN (201-250): 3.15e-09: 61.6: 28.00
+	Mm
		554867 AKT1_MOUSE (397-605): 1.55e-17: 88.6: 11.16		KPCE_MOUSE (151-250): 4.12e-23: 105: 18.35
+	Hs
		681803 AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70		KPCD_HUMAN (153-250): 5.85e-21: 98.6: 17.93
+	Hs
		408561 AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70		KPCB_HUMAN (151-269): 6.29e-21: 98.3: 15.00
+	Hs
		566359 KPCE_HUMAN (397-485): 1.73e-14: 80.1: 15.73		KPCA_HUMAN (151-250): 2.8e-20: 96.3: 16.83
+	Hs
		681799 AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70		KPCT_HUMAN (201-250): 1.39e-14: 78.6: 24.00
+	Hs
		981046 KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37		KPCT_HUMAN (201-250): 1.39e-14: 78.6: 24.00
+	Hs
		981056 KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37		GRP3_HUMAN (201-250): 3.15e-09: 61.6: 28.00