HitPredict

Interactor 1: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 984 Hs			1 779
+	Hs
		1081971 PKN1_HUMAN (15-984): 0: 940: 56.24		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		850712 KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		984534 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1073480 KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		397159 KPCG_HUMAN (497-980): 2.52e-147: 456: 33.52		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		1160283 PKN3_HUMAN (12-215): 6.12e-17: 88.2: 20.69		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682023 AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		981062 KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566481 KPCA_HUMAN (397-560): 2.39e-14: 79.4: 12.65		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		623884 KPCL_HUMAN (397-567): 7.85e-13: 74.7: 10.98		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408682 KPCB_HUMAN (397-486): 3.14e-12: 72.4: 14.44		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		984488 KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		1071703 KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		681831 AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (397-574): 4.25e-16: 84.4: 11.17		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		1148919 PKN3_HUMAN (12-215): 6.12e-17: 88.2: 20.69		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		969077 KPCE_HUMAN (397-485): 1.73e-14: 80.1: 15.73		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		566377 KPCA_HUMAN (397-560): 2.39e-14: 79.4: 12.65		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		408612 KPCB_HUMAN (397-486): 3.14e-12: 72.4: 14.44		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28