HitPredict

Interactor 1: CRY1 (Q16526)
Cryptochrome-1
Gene: CRY1

Interactor 2: CRY2 (Q49AN0)
Cryptochrome-2
Gene: CRY2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

The method score is based on:

Property	Details
Experiments	25756610, 28514442, 33961781, 23133559
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	DNA_photolyase~DNA_photolyase, DNA_photolyase~FAD_binding_7, FAD_binding_7~FAD_binding_7
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 19 others more... GO:0007623 - circadian rhythm GO:0009416 - response to light stimulus GO:0009785 - blue light signaling pathway GO:0009882 - blue light photoreceptor activity GO:0014823 - response to activity GO:0016922 - nuclear receptor binding GO:0019901 - protein kinase binding GO:0019902 - phosphatase binding GO:0019915 - lipid storage GO:0032868 - response to insulin GO:0032922 - circadian regulation of gene expression GO:0042593 - glucose homeostasis GO:0042752 - regulation of circadian rhythm GO:0042754 - negative regulation of circadian rhythm GO:0043153 - entrainment of circadian clock by photoperiod GO:0045892 - negative regulation of DNA-templated transcription GO:0071949 - FAD binding GO:2000323 - negative regulation of glucocorticoid receptor signaling pathway GO:2000850 - negative regulation of glucocorticoid secretion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	586
Hs

1	593

+

Mm

+

Hs

+

Hs

+

At

+

At

+

At

+

Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024