HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.922

Property	Details
Experiments	25795299, 29738775, 31911655, 34026424, 23238014
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 425
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (1-254): 1.38e-58: 196: 14.83
+	Hs
		997738 DDB1_HUMAN (1-1140): 0: 1424: 100.00		RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61
+	Hs
		1082355 DDB1_HUMAN (1-1140): 0: 1424: 100.00		GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47
+	At
		1340748 DDB1A_ARATH (2-1140): 0: 1255: 52.09		HTD1_ARATH (27-396): 4.7e-74: 240: 26.28
+	At
		187019 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI4_ARATH (1-279): 1.33e-32: 130: 13.16
+	At
		187004 DDB1B_ARATH (3-1140): 0: 1248: 50.92		MSI4_ARATH (1-279): 1.33e-32: 130: 13.16
+	At
		186951 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI3_ARATH (268-420): 1.24e-24: 106: 23.42
+	At
		186950 DDB1B_ARATH (3-1140): 0: 1248: 50.92		MSI3_ARATH (268-420): 1.24e-24: 106: 23.42
+	At
		186944 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI1_ARATH (1-167): 6.72e-18: 87.1: 7.53
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (202-424): 3.82e-45: 164: 21.15
+	Hs
		267761 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		TAF5L_HUMAN (32-291): 7.24e-42: 157: 16.48
+	Ce
		219829 O44985_CAEEL (3-1126): 0: 1035: 19.76		LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16
+	Hs
		1073127 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (202-424): 3.82e-45: 164: 21.15
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (1-255): 1.65e-36: 143: 17.31
+	Ce
		954081 CPSF1_CAEEL (3-565): 2.56e-112: 384: 22.27		LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16