HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: DCA10 (Q5QP82)
DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)
Gene: DCAF10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	35271311, 16964240, 16949367
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 559
+	Mm
		57207 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DCA10_MOUSE (1-559): 1.04e-96: 307: 87.50
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (12-325): 5.26e-48: 171: 12.50
+	Hs
		1082381 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SKI8_HUMAN (130-325): 4.55e-40: 149: 26.40
+	Mm
		1112307 DDB1_MOUSE (1-1140): 0: 1422: 99.65		SKI8_MOUSE (130-325): 1.46e-39: 147: 25.38
+	Hs
		921580 DDB1_HUMAN (1-1140): 0: 1424: 100.00		GBB2_HUMAN (184-555): 2.19e-26: 111: 13.64
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (333-557): 6.41e-23: 102: 9.21
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (404-558): 4.98e-21: 96.3: 13.55
+	Hs
		1082480 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WSB1_HUMAN (171-322): 3.49e-13: 73.6: 22.56
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (378-557): 1.15e-12: 72.4: 7.74
+	Hs
		1082427 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WSB2_HUMAN (171-348): 7.11e-12: 69.4: 23.56
+	At
		1340746 DDB1A_ARATH (2-1140): 0: 1255: 52.09		VIP3_ARATH (171-325): 1.13e-26: 112: 20.86
+	At
		221835 DDB1B_ARATH (3-1140): 0: 1248: 50.92		VIP3_ARATH (171-325): 1.13e-26: 112: 20.86
+	Hs
		1073144 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		SKI8_HUMAN (130-325): 4.55e-40: 149: 26.40
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (390-556): 5.65e-18: 89: 13.30
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (381-555): 1.12e-15: 82.5: 12.78
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (202-557): 1.09e-49: 185: 13.37
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (390-556): 5.65e-18: 89: 13.30