HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: PHIP (Q8WWQ0)
PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)
Gene: PHIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	16949367, 29089422, 30018425, 31911655, 33503431, 34171797, 35320725, 37689310, 37071682, 16964240
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1140 Hs			1 1821
+	Hs
		1016284 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL3_HUMAN (7-495): 2.68e-90: 315: 14.31
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (299-580): 2.26e-57: 210: 13.71
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (355-666): 5.05e-55: 198: 13.23
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (422-708): 3.76e-50: 183: 11.41
+	Hs
		1082415 DDB1_HUMAN (1-1140): 0: 1424: 100.00		BRWD1_HUMAN (1-298): 6.14e-41: 168: 15.76
+	Mm
		1112292 DDB1_MOUSE (1-1140): 0: 1422: 99.65		BRWD1_MOUSE (1-298): 1.6e-40: 167: 15.46
+	Hs
		1082241 DDB1_HUMAN (1-1140): 0: 1424: 100.00		BRWD3_HUMAN (1-298): 2.1e-39: 163: 13.65
+	Mm
		57142 DDB1_MOUSE (1-1140): 0: 1422: 99.65		BRWD3_MOUSE (1-298): 3.07e-39: 163: 13.65
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (423-696): 1.86e-26: 118: 13.03
+	Mm
		291405 DDB1_MOUSE (1-1140): 0: 1422: 99.65		WDR1_MOUSE (433-782): 9.04e-16: 85: 10.27
+	Dm
		1362710 DDB1_DROME (1-1140): 0: 1237: 60.84		Q9VC96_DROME (1-298): 1.15e-38: 161: 15.96
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		1073125 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		TEP1_HUMAN (4-454): 7.05e-35: 148: 7.87
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (1-79): 1.4e-13: 77.6: 12.66
+	Hs
		267761 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		TAF5L_HUMAN (260-496): 8.94e-09: 62.4: 26.16
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (181-311): 6.96e-09: 63.2: 32.58
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (161-392): 4.53e-18: 92.8: 28.33
+	Hs
		197009 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		PRP4_HUMAN (160-494): 2.06e-16: 86.7: 25.35
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (1-79): 1.4e-13: 77.6: 12.66