HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	29991511, 37689310, 17079684
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1140 Hs			1 446
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (94-292): 5.97e-27: 115: 14.08
+	Hs
		1082202 DDB1_HUMAN (1-1140): 0: 1424: 100.00		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997738 DDB1_HUMAN (1-1140): 0: 1424: 100.00		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (348-445): 9.02e-15: 76.9: 16.33
+	Mm
		1112274 DDB1_MOUSE (1-1140): 0: 1422: 99.65		WDR59_MOUSE (259-382): 3.17e-13: 73.9: 29.03
+	At
		187019 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI4_ARATH (4-444): 1.59e-66: 222: 19.18
+	At
		187004 DDB1B_ARATH (3-1140): 0: 1248: 50.92		MSI4_ARATH (4-444): 1.59e-66: 222: 19.18
+	Hs
		1073127 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	At
		1340748 DDB1A_ARATH (2-1140): 0: 1255: 52.09		HTD1_ARATH (212-444): 1.47e-29: 121: 17.06
+	At
		186944 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI1_ARATH (307-445): 6.04e-14: 75.4: 16.89
+	At
		186951 DDB1A_ARATH (2-1140): 0: 1255: 52.09		MSI3_ARATH (308-442): 4.02e-09: 60.4: 15.07
+	At
		186950 DDB1B_ARATH (3-1140): 0: 1248: 50.92		MSI3_ARATH (308-442): 4.02e-09: 60.4: 15.07
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89
+	Hs
		1073029 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		WDR59_HUMAN (259-382): 1.24e-12: 72: 28.23
+	Ce
		219829 O44985_CAEEL (3-1126): 0: 1035: 19.76		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (250-445): 1.54e-31: 129: 16.75
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (297-445): 3.11e-19: 92.4: 11.44
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89
+	Ce
		954081 CPSF1_CAEEL (3-565): 2.56e-112: 384: 22.27		LIN53_CAEEL (41-247): 1.86e-21: 97.7: 10.33