HitPredict - High confidence protein-protein interactions

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.835

Property	Details
Experiments	11916974, 24189400, 21675959
Identification Methods	pull down, affinity chromatography technology, protein complementation assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CDC37_M~CDC37_N
Common GO terms	GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0006605 - protein targeting and 16 others more... GO:0010608 - post-transcriptional regulation of gene expression GO:0019887 - protein kinase regulator activity GO:0019900 - kinase binding GO:0019901 - protein kinase binding GO:0031072 - heat shock protein binding GO:0050821 - protein stabilization GO:0051082 - unfolded protein binding GO:0051087 - protein-folding chaperone binding GO:0051879 - Hsp90 protein binding GO:0060334 - regulation of type II interferon-mediated signaling pathway GO:0060338 - regulation of type I interferon-mediated signaling pathway GO:0070062 - extracellular exosome GO:0097110 - scaffold protein binding GO:0098779 - positive regulation of mitophagy in response to mitochondrial depolarization GO:0101031 - protein folding chaperone complex GO:1990565 - HSP90-CDC37 chaperone complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	378
Hs

1	378

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Last updated: 15 Jul 2024