HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 378 Hs			1 822
+	Hs
		1081495 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607988 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		609305 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384911 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		508026 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601520 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		665401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		665253 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		434207 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		968308 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		1079717 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		Q15850_HUMAN (478-820): 1.97e-116: 361: 33.52
+	Hs
		1082788 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		994639 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		435654 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411399 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		968388 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		537743 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		1083044 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		666606 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		169179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92