HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35384245, 25036637
Identification Methods	proximity labelling technology, affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 855
+	Hs
		994639 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		DDR1_HUMAN (22-849): 0: 655: 52.08
+	Hs
		1082785 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Hs
		508026 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		601520 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR2_HUMAN (522-851): 6.41e-102: 336: 34.42
+	Hs
		384911 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		609305 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR3_HUMAN (485-851): 5.88e-101: 333: 31.28
+	Hs
		1081495 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		169179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MUSK_HUMAN (557-854): 3.25e-98: 327: 39.42
+	Hs
		607988 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78
+	Hs
		412211 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FYN_HUMAN (548-850): 3.85e-99: 320: 35.64
+	Hs
		433368 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		YES_HUMAN (556-850): 2.32e-97: 316: 34.58
+	Hs
		523006 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Hs
		1079717 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		Q15850_HUMAN (533-852): 3.17e-98: 315: 30.95
+	Hs
		435654 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		968308 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ROR1_HUMAN (556-849): 2.13e-58: 217: 39.87
+	Hs
		411399 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		968388 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39
+	Hs
		665401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA3_HUMAN (554-845): 1.09e-54: 206: 38.93