HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	26355680, 20642453, 18367605, 22612223, 16321986, unassigned1853, 23075850
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 2527
+	Mm
		1130110 CDC37_MOUSE (1-377): 2.28e-166: 471: 94.97		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		788966 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MATK_HUMAN (1683-2160): 3.41e-106: 352: 20.43
+	Hs
		782791 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	Hs
		1082790 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		972460 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	Hs
		201342 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Mm
		1142130 CDC37_MOUSE (1-377): 2.28e-166: 471: 94.97		M3K7_MOUSE (1869-2132): 1.06e-22: 107: 28.83