HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.50	0.565

Property	Details
Experiments	32707033, 35384245
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 378 Hs			1 422
+	Hs
		508026 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		609305 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR3_HUMAN (10-409): 1.6e-125: 383: 27.01
+	Hs
		601520 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		665401 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		665253 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		872447 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		665610 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		1072507 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37
+	Hs
		434207 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		1083031 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA6_HUMAN (7-407): 1.54e-118: 371: 19.28
+	Hs
		872655 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		169179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		607988 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		523006 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		412211 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		433368 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		789071 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63
+	Hs
		725309 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		TIE1_HUMAN (120-380): 8.51e-36: 142: 32.96
+	Hs
		782791 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		972330 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		TIE2_HUMAN (146-380): 2.39e-34: 137: 31.56