HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: ULK3 (Q6PHR2)
Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)
Gene: ULK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26186194, 32707033, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 472
+	Hs
		1038971 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2G_HUMAN (1-461): 1.28e-139: 414: 20.69
+	Hs
		1082863 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ULK2_HUMAN (20-280): 1.15e-50: 187: 39.34
+	Hs
		262278 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ULK1_HUMAN (4-271): 1.85e-49: 183: 39.93
+	Mm
		250796 CDC37_MOUSE (1-377): 2.28e-166: 471: 94.97		ULK1_MOUSE (14-271): 3.23e-50: 186: 40.38
+	Hs
		1083012 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		STK36_HUMAN (11-282): 1.17e-42: 164: 37.72
+	Hs
		160591 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AURKA_HUMAN (11-270): 2.18e-45: 164: 35.25