HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: MYLK4 (Q86YV6)
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
Gene: MYLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	26186194, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 388
+	Hs
		682179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT2_HUMAN (10-380): 4.47e-137: 401: 22.86
+	Hs
		1083052 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT3_HUMAN (7-386): 4.81e-135: 396: 23.02
+	Hs
		681873 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Hs
		1082978 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		MYLK2_HUMAN (30-388): 3.9e-124: 372: 50.69
+	Hs
		70436 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		B2RB89_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		200116 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		515281 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25
+	Hs
		1082932 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		PSKH2_HUMAN (111-361): 3.66e-53: 182: 38.19
+	Hs
		1083050 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2A_HUMAN (110-362): 3.53e-50: 177: 37.35