HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: SRMS (Q9H3Y6)
Tyrosine-protein kinase Srms (EC 2.7.10.2)
Gene: SRMS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 488
+	Hs
		523006 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SRC_HUMAN (4-482): 0: 554: 38.95
+	Hs
		433368 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		YES_HUMAN (3-482): 0: 551: 39.06
+	Hs
		412211 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FYN_HUMAN (7-482): 0: 550: 38.43
+	Hs
		454835 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		FGR_HUMAN (1-482): 0: 544: 40.24
+	Hs
		442838 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		HCK_HUMAN (26-486): 0: 540: 40.30
+	Hs
		411738 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		LCK_HUMAN (46-483): 0: 527: 42.60
+	Hs
		846474 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		BLK_HUMAN (2-486): 5.3e-180: 515: 39.68
+	Hs
		433785 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		LYN_HUMAN (1-486): 3.42e-179: 513: 36.03
+	Hs
		789071 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ABL2_HUMAN (20-486): 8.5e-169: 508: 36.42
+	Hs
		1082800 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		Q573B4_HUMAN (1-483): 1.51e-167: 484: 35.89
+	Hs
		996564 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ITK_HUMAN (7-486): 6.06e-164: 478: 33.27
+	Hs
		986378 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		BTK_HUMAN (7-478): 6.44e-162: 475: 32.93
+	Hs
		1046404 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		PTK6_HUMAN (44-483): 1.2e-163: 471: 45.19