HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: STK36 (Q9NRP7)
Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)
Gene: STK36

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 17054904
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 1315
+	Hs
		1038874 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2B_HUMAN (2-503): 2.05e-128: 413: 24.58
+	Hs
		682179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT2_HUMAN (1-328): 4.09e-126: 400: 28.36
+	Hs
		1083052 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT3_HUMAN (1-327): 1.07e-125: 399: 28.44
+	Hs
		681873 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT1_HUMAN (1-325): 8.15e-125: 396: 29.43
+	Hs
		1038971 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2G_HUMAN (2-468): 3.25e-122: 392: 24.32
+	Hs
		1082911 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK3_HUMAN (4-253): 5.95e-43: 166: 35.27
+	Hs
		1083049 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AURKC_HUMAN (1-264): 7.61e-45: 166: 36.33
+	Hs
		117008 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK1_HUMAN (4-311): 3.14e-43: 166: 33.33
+	Hs
		1082831 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ULK3_HUMAN (1-270): 2.66e-42: 164: 37.72
+	Hs
		1082996 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		SGK2_HUMAN (4-243): 2.39e-41: 158: 36.18