HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: CD11A (Q9UQ88)
Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)
Gene: CDK11A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	28514442, 33961781, 24189400, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 783
+	Hs
		596761 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CD11B_HUMAN (1-783): 0: 559: 95.85
+	Hs
		625464 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CDK2_HUMAN (423-719): 9.55e-156: 456: 43.62
+	Hs
		960287 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CDK5_HUMAN (423-717): 1.17e-136: 407: 41.55
+	Hs
		414935 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CDK1_HUMAN (423-715): 6.59e-136: 405: 41.36
+	Hs
		1068437 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CDK10_HUMAN (417-748): 5.66e-134: 403: 52.11
+	Hs
		841214 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		CDK7_HUMAN (424-748): 1.27e-73: 245: 38.69
+	Sc
		339332 CDC37_YEAST (2-320): 1.81e-73: 238: 18.34		CDK1_YEAST (426-714): 4.05e-78: 255: 46.94