HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	21903422, 14743216
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 518
+	Hs
		1082987 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		Q9H4D1_HUMAN (20-286): 3.61e-38: 150: 35.74
+	Hs
		883519 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RIPK4_HUMAN (20-374): 1.35e-36: 146: 30.39
+	Hs
		1038259 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		RIPK1_HUMAN (21-288): 1.18e-33: 137: 33.90
+	Hs
		1082884 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		ANKK1_HUMAN (14-294): 1.95e-32: 133: 30.41
+	Hs
		1082810 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		TNI3K_HUMAN (4-291): 2.07e-22: 103: 27.48