Interactor 1: IL17 (Q16552)
Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)
Gene: IL17A
Interactor 2: I17RA (Q96F46)
Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)
Gene: IL17RA
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.964 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 33961781, 9367539, 11058597, 17911633, 18684971, 19838198 |
| Identification Methods | affinity chromatography technology, competition binding, fluorescence-activated cell sorting, solid phase assay, surface plasmon resonance, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL17~IL17R_fnIII_D1, IL17~IL17R_fnIII_D2 |
| Common GO terms | GO:0005576 - extracellular region GO:0006954 - inflammatory response GO:0032747 - positive regulation of interleukin-23 production GO:0032755 - positive regulation of interleukin-6 production GO:0038173 - interleukin-17A-mediated signaling pathway and 6 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
