HitPredict

Interactor 1: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Interactor 2: CHD5 (Q8TDI0)
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)
Gene: CHD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	25247294, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006338 - chromatin remodeling and 2 others more... GO:0016581 - NuRD complex GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Hs			1 1954
+	Hs
		997824 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		CHD5_HUMAN (1-1954): 0: 1751: 100.00
+	Hs
		1018507 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		1059641 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Hs
		1018714 NLE1_HUMAN (202-424): 3.82e-45: 164: 21.15		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		997695 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		929424 RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		997726 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Hs
		929464 RACK1_HUMAN (213-405): 2.23e-28: 115: 20.41		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Hs
		903234 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Dm
		332768 CAF1_DROME (1-209): 8.04e-42: 154: 13.16		CHDM_DROME (15-1942): 0: 1349: 49.51
+	Hs
		229413 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		SMCA5_HUMAN (575-1643): 0: 743: 26.22
+	Hs
		658682 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		SMCA1_HUMAN (584-1628): 0: 724: 25.42
+	Hs
		229377 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		SMCA5_HUMAN (575-1643): 0: 743: 26.22
+	Dm
		1097621 CAF1_DROME (1-209): 8.04e-42: 154: 13.16		ISWI_DROME (591-1655): 0: 731: 25.72
+	Hs
		658658 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		SMCA1_HUMAN (584-1628): 0: 724: 25.42
+	Hs
		997936 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		CHD7_HUMAN (485-1618): 0: 723: 29.01
+	Ce
		784763 LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16		ISW1_CAEEL (582-1650): 0: 665: 23.97
+	Hs
		903535 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		CHD8_HUMAN (458-1683): 0: 707: 26.48
+	Ce
		954000 LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16		CHD3_CAEEL (1289-1927): 8.2e-86: 315: 27.38
+	Ce
		104626 LIN53_CAEEL (1-209): 6.74e-42: 154: 14.16		LE418_CAEEL (1286-1925): 1.39e-83: 307: 26.40