HitPredict

Interactor 1: C3AR (Q16581)
C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R)
Gene: C3AR1

Interactor 2: CERS6 (Q6ZMG9)
Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)
Gene: CERS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 384
+	Hs
		1083460 C3AR_HUMAN (1-482): 1.62e-98: 306: 100.00		CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96
+	Hs
		1083477 C3AR_HUMAN (1-482): 1.62e-98: 306: 100.00		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		436927 ACM4_HUMAN (2-461): 9.67e-69: 229: 16.50		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		591223 ACM3_HUMAN (2-454): 7.67e-65: 221: 17.59		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		537300 DRD2_HUMAN (5-452): 4.39e-70: 231: 16.23		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		626539 FPR2_HUMAN (316-472): 7.93e-40: 148: 30.91		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		674858 AGTR1_HUMAN (289-481): 8.99e-35: 135: 21.36		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		723335 APJ_HUMAN (298-473): 1.89e-32: 129: 26.20		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		626550 FPR2_HUMAN (316-472): 7.93e-40: 148: 30.91		CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96
+	Hs
		895677 CXCR4_HUMAN (322-457): 2.26e-36: 139: 23.78		CERS5_HUMAN (6-375): 6.65e-154: 440: 64.96
+	Hs
		781078 OPRX_HUMAN (272-482): 2.29e-27: 114: 20.63		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		1168253 CML1_HUMAN (289-479): 4.78e-27: 113: 28.71		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		600824 C5AR1_HUMAN (294-482): 3.03e-38: 144: 27.60		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		600846 C5AR1_HUMAN (294-482): 3.03e-38: 144: 27.60		CERS4_HUMAN (7-370): 1.54e-145: 419: 43.13
+	Hs
		1030979 GPR17_HUMAN (337-450): 2.07e-17: 85.4: 23.33		CERS6_HUMAN (1-384): 8.88e-163: 463: 100.00
+	Hs
		781097 OPRX_HUMAN (272-482): 2.29e-27: 114: 20.63		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		1291792 CML1_HUMAN (289-479): 4.78e-27: 113: 28.71		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		656968 5HT1B_HUMAN (364-454): 2.19e-17: 85.6: 18.68		CERS2_HUMAN (7-342): 1.13e-146: 422: 44.64
+	Hs
		537283 DRD2_HUMAN (5-452): 4.39e-70: 231: 16.23		TRAM1_HUMAN (120-371): 3.28e-69: 224: 19.46
+	Hs
		537256 DRD2_HUMAN (5-452): 4.39e-70: 231: 16.23		CERS1_HUMAN (113-367): 1.15e-60: 200: 33.09