HitPredict

Interactor 1: C3AR (Q16581)
C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R)
Gene: C3AR1

Interactor 2: SPPL3 (Q8TCT6)
Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)
Gene: SPPL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007204 - positive regulation of cytosolic calcium ion concentration
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 384
+	Hs
		600804 C5AR1_HUMAN (294-482): 3.03e-38: 144: 27.60		SPPL3_HUMAN (1-384): 5.65e-136: 395: 100.00
+	Hs
		781090 OPRX_HUMAN (272-482): 2.29e-27: 114: 20.63		SPPL3_HUMAN (1-384): 5.65e-136: 395: 100.00
+	Hs
		1031026 GPR17_HUMAN (337-450): 2.07e-17: 85.4: 23.33		SPPL3_HUMAN (1-384): 5.65e-136: 395: 100.00