HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.40 1.00 0.637

The method score is based on:

Property Details
Experiments 22269274
Identification Methods bimolecular fluorescence complementation, split firefly luciferase complementation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, I-set~LRR_8, LRR_8~LRR_8, LRRCT_2~LRR_8, LRR_8~LRRNT, LRR_8~PK_Tyr_Ser-Thr, LRRNT~LRRNT, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001570 - vasculogenesis
GO:0001764 - neuron migration
GO:0001934 - positive regulation of protein phosphorylation
GO:0002020 - protease binding
GO:0005524 - ATP binding
and 49 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024