HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0046777 - protein autophosphorylation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 1746
+	Hs
		608132 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		385530 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		508196 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665432 EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		434286 RET_HUMAN (436-820): 1.09e-115: 379: 33.00		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1088142 DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		435763 IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		968486 ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1332902 ALK_HUMAN (513-799): 4.96e-64: 236: 41.44		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Rn
		88928 INSR_RAT (513-809): 7.79e-68: 247: 42.72		D4A563_RAT (1-1746): 0: 2074: 85.98
+	Hs
		607895 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		507876 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		507838 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		665151 EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568557 EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		508055 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		OBSCN_HUMAN (933-1713): 2.16e-56: 220: 11.37
+	Hs
		435552 IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568630 ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		851514 DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40		NEK4_HUMAN (1483-1657): 6.72e-12: 72.9: 21.91